Bioimpedance measurements to determine fluid volume distribution in desoxycorticosterone acetate (DOCA)‐salt hypertension

Desoxycorticosterone Acetate

1. Desoxycorticosterone acetate (DCA) and NaCl, in the dosage employed in normal rats, caused renal and cardiac hypertrophy, characteristic changes in the renal tubular epithelium, atrophic changes in the subcapsular zone of the adrenal cortex, and serum electrolyte changes characterized by a rise in sodium and fall in potassium. 2. In rats rendered nephritic with a rabbit anti-rat-kidney serum...

Sustained Hypertension following the Administration of Desoxycorticosterone Acetate

DCA was administered in two separate experiments to rats in amounts sufficient to cause marked elevation of the blood pressure. It was then abruptly withdrawn. Following this treatment, observations of blood pressure, blood urea nitrogen, plasma potassium, and plasma volume were carried out for over a year. Approximately one-third of the animals so treated developed a sustained, permanent hyper...

The effect of desoxycorticosterone acetate on water and electrolyte distribution.

Desoxycorticosterone Acetate and Wound Healing

The effect of desoxycorticosterone acetate (DCA) on the granulation tissue of healing and healed linear laparotomy wounds was studied in young adult male guinea pigs maintained on a complete diet and on a known intake of ascorbic acid. DCA induces the production of an excessive amount of granulation tissue, as evidenced by a relatively great number of fibroblasts and by a larger amount of groun...

Observations on the Rôle of the Rat Kidney in Hypertension Caused by Desoxycorticosterone Acetate

Desoxycorticosterone acetate in pellet form was administered for 51 days to albino rats of the Sherman strain which also received 1 per cent saline as drinking water. Treatment was stopped in representative groups at 25, 37, and 51 days so that the regression of blood pressure and renal changes could be observed. It was noted that both the elevation in blood pressure during treatment and its re...